Research Article
Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations
Table 3
Pain response versus plasma concentration of dexibuprofen (test product).
| Time points (h) | Pain response | Plasma concentration (g/mL) | | | | | | | | | | | | |
| 0 | 1.1 | 0.5 | 2.3 | 1.4 | 2.4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.1 | 3.5 | 5.4 | 4.4 | 5.7 | 4.1 | 7.1254 | 7.5624 | 5.2039 | 8.1283 | 6.9584 | 7.9892 | 4 | 9.3 | 8.6 | 9.4 | 9.1 | 9.7 | 9.8 | 13.5241 | 10.0548 | 12.5264 | 11.9856 | 9.5321 | 12.6354 | 6 | 9.9 | 9.6 | ā | 9.8 | 9.9 | ā | 9.1032 | 12.1627 | 9.9287 | 9.9012 | 12.9658 | 8.7541 |
|
|
Volunteers code.
|