Research Article
Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations
Table 4
Pain response versus plasma concentration of dexibuprofen (reference product).
| Time points (h) | Pain response | Plasma concentration (mcg/mL) | | | | | | | | | | | | |
| 0 | 0.7 | 0.6 | 1.7 | 1.6 | 2.1 | 1.3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.3 | 2.9 | 4.3 | 3.7 | 4.6 | 3.7 | 5.9826 | 6.3614 | 4.6985 | 7.4978 | 7.3956 | 5.3869 | 4 | 8.9 | 7.5 | 6.9 | 7.4 | 8.5 | 6.4 | 12.4958 | 11.3057 | 12.0498 | 10.2584 | 12.0394 | 13.0695 | 6 | 9.2 | 8.5 | 8.7 | 9 | 9.3 | 8.9 | 8.9375 | 9.5473 | 8.9573 | 8.5893 | 9.2738 | 9.4752 |
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