Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT_1A Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis for the Development of Schizophrenia

Figure 4

[³H]8-OH-DPAT binding (fmoles/mg tissue equivalent (TE)) to serotonin 5HT_1A receptor in CA1 region of the hippocampus in offspring from poly I:C treated dams and received 100 μg/kg HU210 (POLY-HU210) or vehicle (POLY-VEH) for 14 days beginning on postnatal day (PND) 35, and offspring from PBS-treated dams and received 100 μg/kg HU210 (VEH-HU210) or vehicle (VEH-VEH). Offspring were euthanized on PNDs 55, 65, and 90. In Bonferroni post hoc tests, 0.0001<^∗𝑃<0.05 compared to VEH-VEH group; 0.0001<^$𝑃<0.05 compared to POLY-VEH group; 0.0001<^#𝑃<0.05 compared to VEH-HU210 group (𝑛 = 6–8 per treatment group at each time point).