Research Article

Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis for the Development of Schizophrenia

Table 3

[3H]8-OH-DPAT binding to serotonin 5 H T 1 A receptor in layers I–III (CTXUP) and IV–VI (CTXDO) of somatosensory cortex and CA1 region of hippocampus (CA1).

VEH-VEHVEH-HU210Poly I:C-VEHPoly I:C-HU210
PND 55PND 65PND 90PND 55PND 65PND 90PND 55PND 65PND 90PND 55PND 65PND 90

CA1 6 0 . 0 8 ± 3 . 3 9 6 0 . 3 7 ± 2 . 8 0 5 8 . 0 1 ± 2 . 2 3 6 1 . 3 2 ± 3 . 4 4 6 7 . 1 6 ± 5 . 0 0 5 5 . 6 4 ± 3 . 9 7 7 0 . 4 0 ± 2 . 4 8 7 1 . 1 9 ± 5 . 0 1 6 6 . 9 0 ± 2 . 0 4 8 6 . 4 3 ± 1 . 8 6 7 8 . 0 9 ± 2 . 7 1 8 0 . 8 1 ± 4 . 6
CTXUP 1 4 . 8 7 ± 1 . 3 4 1 3 . 4 0 ± 0 . 8 0 1 2 . 3 6 ± 1 . 1 8 1 4 . 8 1 ± 0 . 6 9 1 7 . 2 1 ± 2 . 0 8 1 1 . 5 2 ± 1 . 2 5 1 1 . 6 9 ± 0 . 7 2 1 1 . 5 0 ± 1 . 1 3 1 0 . 1 6 ± 0 . 9 8 1 3 . 8 7 ± 1 . 1 9 1 3 . 0 2 ± 1 . 1 7 9 . 2 9 ± 1 . 2 2
CTXDO 2 7 . 7 8 ± 1 . 9 6 2 3 . 7 2 ± 1 . 0 2 2 5 . 6 5 ± 1 . 5 6 2 5 . 6 3 ± 1 . 2 2 2 8 . 1 6 ± 1 . 9 4 2 3 . 4 7 ± 1 . 2 5 2 3 . 8 8 ± 2 . 0 6 2 3 . 4 1 ± 1 . 5 0 2 2 . 0 1 ± 1 . 2 9 2 4 . 4 2 ± 1 . 2 4 2 4 . 9 6 ± 1 . 0 3 2 3 . 1 1 ± 1 . 5 1

Data are presented as average ± SEM of 𝑛 Ci/mg Tissue Equivalent ( 𝑛 = 6 –8 per group).