Role of Gut-Related Peptides and Other Hormones in the Amelioration of Type 2 Diabetes after Roux-en-Y Gastric Bypass Surgery

Table 3

GIP and RYGB surgery.

Author/year	Type of study	Subjects	Preop BMI	% weight loss	F/U time	Change in hormone
Laferrère et al. 2007 [50]	Prospective controlled	8 F T2D RYGB; 7 nondiabetic obese	43.6±6.8; 37.1±11.6	NA	1 mo	Fasting- and glucose-stimulated GIP similar in S and C; 1 month after RYGB, increase in GIP in response to oral glucose.
Laferrère et al. 2008 [49]	Prospective controlled	9 F T2D RYGB; 10 F T2D diet-induced weight loss	43.3±6.2; 43.3±3.6	NA	1 mo; 10 Kg weight loss	No change in fasting GIP in both groups.; Increase in peak GIP after OGTT in RYGB group only.
Rubino et al., 2004 [60]	Prospective uncontrolled	10 (9 F, 6 T2D) obese RYGB	46.2	NA	3 wk	Baseline GIP higher in diabetics compared to nondiabetics.; Decrease in fasting GIP in diabetics only.
Clements et al. 2004 [61]	Prospective uncontrolled	20 obese (15 F) with T2D	52.7±8.8	NA	2, 6 and 12 wk postop	Decrease in fasting GIP at 6 and 12 wk.
Whitson et al. 2007 [72]	Prospective uncontrolled	10 (9 F, 5 T2D); RYGB	50±6	NA	6 mo	No change in GIP postop (nonfasting).
Kashyap et al. 2010 [73]	Prospective uncontrolled	16 (7 females); T2D; 9 RYGB; 7 GR	47±9	10%	4 wk	No change in fasting or PP GIP in both groups.
Korner et al. 2007 [58]	Cross-sectional controlled	13 F RYGB; 10 F BND; 13 F overweight	31.3±1.3; 36.1±1.7; 36.1±2.2	35.6±2.4; 24.6±2.3	24.6±2 mo postop	Blunted PP GIP peak after RYGB

Abbreviations: BND: adjustable gastric banding, GR: gastric restrictive, NA: data not available, OGTT: oral glucose tolerance test, Postop: postoperatively, PP: postprandial, RYGB: Roux-en-y gastric bypass, T2D: type 2 diabetes.