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ISRN Immunology
Volume 2012 (2012), Article ID 530179, 9 pages
http://dx.doi.org/10.5402/2012/530179
Clinical Study

Resection and Immunotherapy for Recurrent Grade III Glioma

1Department of Child & Women, University Hospital Leuven, Catholic University of Leuven, 3000 Leuven, Belgium
2Department of Neurosurgery, University Hospital Leuven, Catholic University of Leuven, 3000 Leuven, Belgium
3Department of Experimental Medicine, University Hospital Leuven, Catholic University of Leuven, 3000 Leuven, Belgium
4Pediatric Hemato-Oncology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium

Received 27 September 2011; Accepted 10 November 2011

Academic Editors: A. Rebollo and S. Vuckovic

Copyright © 2012 Iris Elens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Despite surgery, radiotherapy, and chemotherapy, the prognosis of relapsed grade III gliomas remains poor. After promising results of immunotherapy in grade IV gliomas, we investigated its safety and efficacy in recurrent grade III gliomas. Methods. Thirty-nine patients received vaccines containing dendritic cells loaded with autologous tumor lysate after tumor resection. Progression-free survival (PFS) and overall survival (OS) were compared with those obtained after temozolomide (TMZ) treatment as found in the literature. Results. Median PFS and OS were 4.6 and 20.5, 3.4 and 18.8, 7.8 and 13.3 months in recurrent grade III astrocytoma, oligodendroglioma, and oligoastrocytoma, respectively. Compared with TMZ, no grade III/IV toxicity was reported and median OS tended to be higher although there was no difference in median PFS. The perceived benefit of immunotherapy was more pronounced in astrocytic tumors. Conclusions. We provide the first description of immunotherapy in recurrent grade III glioma as safe, promising, and feasible.