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ISRN Immunology
Volume 2012 (2012), Article ID 530179, 9 pages
http://dx.doi.org/10.5402/2012/530179
Clinical Study

Resection and Immunotherapy for Recurrent Grade III Glioma

1Department of Child & Women, University Hospital Leuven, Catholic University of Leuven, 3000 Leuven, Belgium
2Department of Neurosurgery, University Hospital Leuven, Catholic University of Leuven, 3000 Leuven, Belgium
3Department of Experimental Medicine, University Hospital Leuven, Catholic University of Leuven, 3000 Leuven, Belgium
4Pediatric Hemato-Oncology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium

Received 27 September 2011; Accepted 10 November 2011

Academic Editors: A. Rebollo and S. Vuckovic

Copyright © 2012 Iris Elens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Ohgaki and P. Kleihues, “Epidemiology and etiology of gliomas,” Acta Neuropathologica, vol. 109, no. 1, pp. 93–108, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. D. N. Louis, H. Ohgaki, O. D. Wiestler et al., “The 2007 WHO classification of tumours of the central nervous system,” Acta Neuropathologica, vol. 114, pp. 97–109, 2007.
  3. S. Pfister, C. Hartmann, and A. Korshunov, “Histology and molecular pathology of pediatric brain tumors,” Journal of Child Neurology, vol. 24, no. 11, pp. 1375–1386, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. G. Dresemann, “Temozolomide in malignant glioma,” Journal of OncoTargets and Therapy, vol. 3, pp. 139–146, 2010.
  5. M. K. Khan, G. K. Hunter, M. Vogelbaum, J. H. Suh, and S. T. Chao, “Evidence-based adjuvant therapy for gliomas: current concepts and newer developments,” Indian Journal of Cancer, vol. 46, no. 2, pp. 96–107, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. R. A. Kristof, G. Neuloh, V. Hans et al., “Combined surgery, radiation, and PCV chemotherapy for astrocytomas compared to oligodendrogliomas and oligoastrocytomas WHO grade III,” Journal of Neuro-Oncology, vol. 59, no. 3, pp. 231–237, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. R. P. Sanders, M. Kocak, P. C. Burger, T. E. Merchant, A. Gajjar, and A. Broniscer, “High-grade astrocytoma in very young children,” Pediatric Blood and Cancer, vol. 49, no. 7, pp. 888–893, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. C. Balmaceda, D. Peereboom, S. Pannullo et al., “Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas,” Cancer, vol. 112, no. 5, pp. 1139–1146, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. S. M. Chang, P. Theodosopoulos, K. Lamborn et al., “Temozolomide in the treatment of recurrent malignant glioma,” Cancer, vol. 100, no. 3, pp. 605–611, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. O. L. Chinot, S. Honore, H. Dufour et al., “Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy,” Journal of Clinical Oncology, vol. 19, no. 9, pp. 2449–2455, 2001. View at Scopus
  11. M. J. van den Bent, F. Keime-Guibert, A. A. Brandes et al., “Temozolomide chemotherapy in recurrent oligodendroglioma,” Neurology, vol. 57, no. 2, pp. 340–342, 2001. View at Scopus
  12. M. J. van den Bent, O. Chinot, W. Boogerd et al., “Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972,” Annals of Oncology, vol. 14, no. 4, pp. 599–602, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. M. J. van den Bent, M. J. Taphoorn, A. A. Brandes et al., “Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971,” Journal of Clinical Oncology, vol. 21, no. 13, pp. 2525–2528, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. W. K. Yung, M. D. Prados, R. Yaya-Tur et al., “Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group,” Journal of Clinical Oncology, vol. 17, no. 9, pp. 2762–2771, 1999.
  15. H. Ardon, B. Verbinnen, W. Maes, T. Beez, S. van Gool, and S. de Vleeschouwer, “Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccination,” Journal of Immunological Methods, vol. 352, no. 1-2, pp. 169–173, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. W. Maes, C. Deroose, V. Reumers et al., “In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma,” Journal of Neuro-Oncology, vol. 91, no. 2, pp. 127–139, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. W. Maes, G. G. Rosas, B. Verbinnen et al., “DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma,” Neuro-Oncology, vol. 11, no. 5, pp. 529–542, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. H. Ardon, S. van Gool, I. S. Lopes et al., “Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study,” Journal of Neuro-Oncology, vol. 99, no. 2, pp. 261–272, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. H. Ardon, S. de Vleeschouwer, F. van Calenbergh et al., “Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumours,” Pediatric Blood and Cancer, vol. 54, no. 4, pp. 519–525, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. S. de Vleeschouwer, S. Fieuws, S. Rutkowski et al., “Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme,” Clinical Cancer Research, vol. 14, no. 10, pp. 3098–3104, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. S. de Vleeschouwer, M. Rapp, R. V. Sorg et al., “Dendritic cell vaccination in patients with malignant gliomas: current status and future directions,” Neurosurgery, vol. 59, no. 5, pp. 988–999, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. N. K. Foreman and A. M. Donson, “Tumor vaccination for malignant brain tumors,” Pediatric Blood and Cancer, vol. 54, no. 4, pp. 495–496, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. S. van Gool, W. Maes, H. Ardon, T. Verschuere, S. van Cauter, and S. de Vleeschouwer, “Dendritic cell therapy of high-grade gliomas,” Brain Pathology, vol. 19, no. 4, pp. 694–712, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. C. G. Drake, “Prostate cancer as a model for tumour immunotherapy,” Nature Reviews Immunology, vol. 10, no. 8, pp. 580–593, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. S. van Gool, “The dendritic therapy with its potential applications in pancreatic cancer,” Acta Gastro-Enterologica Belgica, vol. 72, no. 3, pp. 338–343, 2009. View at Scopus
  26. H. van Poppel, S. Joniau, and S. W. van Gool, “Vaccine therapy in patients with renal cell carcinoma,” European Urology, vol. 55, no. 6, pp. 1333–1342, 2009.
  27. J. Weber, “Immunotherapy for melanoma,” Current Opinion in Oncology, vol. 23, pp. 163–169, 2011.
  28. J. M. Timmerman and R. Levy, “Dendritic cell vaccines for cancer immunotherapy,” Annual Review of Medicine, vol. 50, pp. 507–529, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Scopus
  30. S. de Vleeschouwer, M. Arredouani, M. Adé et al., “Uptake and presentation of malignant glioma tumor cell lysates by monocyte-derived dendritic cells,” Cancer Immunology, Immunotherapy, vol. 54, no. 4, pp. 372–382, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. S. de Vleeschouwer, F. van Calenbergh, P. Demaerel et al., “Transient local response and persistent tumor control in a child with recurrent malignant glioma: treatment with combination therapy including dendritic cell therapy: case report,” Journal of Neurosurgery, vol. 100, no. 5, pp. 492–497, 2004. View at Scopus
  32. S. Rutkowski, S. de Vleeschouwer, E. Kaempgen et al., “Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study,” British Journal of Cancer, vol. 91, no. 9, pp. 1656–1662, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. R. K. Hales, O. Shokek, P. C. Burger et al., “Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis,” Journal of Neuro-Oncology, vol. 99, no. 1, pp. 65–71, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. H. Ohgaki and P. Kleihues, “Genetic alterations and signaling pathways in the evolution of gliomas,” Cancer Science, vol. 100, no. 12, pp. 2235–2241, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. S. Nobusawa, T. Watanabe, P. Kleihues, and H. Ohgaki, “IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas,” Clinical Cancer Research, vol. 15, no. 19, pp. 6002–6007, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. H. Ohgaki, P. Dessen, B. Jourde et al., “Genetic pathways to glioblastoma: a population-based study,” Cancer Research, vol. 64, no. 19, pp. 6892–6899, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. H. Yan, D. W. Parsons, G. Jin et al., “IDH1 and IDH2 mutations in gliomas,” New England Journal of Medicine, vol. 360, no. 8, pp. 765–773, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. M. Eoli, F. Menghi, M. Bruzzone et al., “Methylation of O6-methylguanine DNA methytransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival,” Clinical Cancer Research, vol. 13, no. 9, pp. 2606–2613, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. “CTC criteria version 3.0. Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events version 3.0, DCTD, NCI, NIH, DHHS,” 2006.
  40. C. Lebrun, D. Fontaine, A. Ramaioli et al., “Long-term outcome of oligodendrogliomas,” Neurology, vol. 62, no. 10, pp. 1783–1787, 2004. View at Scopus
  41. H. Ohgaki and P. Kleihues, “Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas,” Journal of Neuropathology and Experimental Neurology, vol. 64, no. 6, pp. 479–489, 2005. View at Scopus
  42. M. van den Bent, J. Kros, J. Heimans et al., “Response rate and prognostic factors of recurrent oligodendroglioma treated with procarbazine, CCNU, and vincristine chemotherapy. Dutch Neuro-oncology Group,” Neurology, vol. 51, no. 4, pp. 1140–1145, 1998.
  43. A. Brandes, A. Tosoni, F. Vastola et al., “Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent radiotherapy. A phase II study,” Cancer, vol. 101, no. 9, pp. 2079–2085, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus