Recent Advances in Obesity: Genetics and Beyond

Table 1

Overview of main obesity-susceptibility loci identified through candidate gene and genome-wide association studies.

Chromosomal location	Gene symbol	Gene name
1p31.1	NEGR1	Neuronal growth regulator 1
1q41	LYPLA1	Lysophospholipase-like 1
1q25.2	SEC16B	SEC 16 homologue B
	RASAL2	RAS protein activator like 2
2p25.3	TMEN18	Transmembrane protein 18
2q14.1	INSIG2	Insulin-induced gene 2
3q27	ETV5	Ets variant gene 5
4p13	GNPDA2	Glucosamine-6-phosphate deaminase 2
5q13.3	CART	Cocaine-and amphetamine-regulated transcript
5q15-q21	PCSK1	Prohormone convertase 1/3
6p12	TFAP2B	Transcription factor AP-2β
6p22.2-p21.3	PRL	Prolactin
6q14-q15	CNR1	Endocannabinoid receptor 1
8p12-p11.2	ADRB3	Adrenergic β3 receptor
8p23.1	MSRA	Methionine sulfoxide reductase A
10p12	PTER	Phosphotriesterase related
11p11.2	MTCH2	Mitochondrial carrier homologue 2
11p13	BDNF	Brain-derived neurotrophic factor
12q13	BCDIN3D	BCDIN3-domain-containing
	FAIM2	FAS apoptotic inhibitory molecule 2
14q31	NRXN3	Neurexin 3
16p11.2	SH2B1	SH2B adaptor protein 1
	ATP2A1	ATPase, Ca^2+ transporting, cardiac muscle, fast twitch 1
16q12.2	FTO	Fat mass and obesity-associated gene
16q22-q23	MAF v	Maf musculoaponeurotic fibrosarcoma oncogene homologue
18q11-q12	NPC1	Niemann-Pick disease, type C1
18q22	MC4R	Melanocortin 4 receptor
19q13.11	KCTD15	Potassium channel tetramerisation domain containing 15
19q31	CHST8	Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
Xq23-24	SLC6A14	Solute carrier family 6 member 14
	CUL4B	Cullin 4B