Necrotizing Enterocolitis in Very Low Birth Weight Infants: A Systemic Review

Table 2

Clinical trials of probiotic preparations to decrease the incidence of neonatal NEC.

Study	Site/patient population	Probiotic administration	Decrease in NEC
Hoyos et al. [61]	Bogota Columbia all admitted newborns historical controls singal site-1237 infants	Daily infloran until D/C (L acidophilus, B. infantis)	2.9% versus 6.6%
Lin et al. [62]	Taiwan VLBW < 1500 g prospective, masked randomized control trial singal site-367 infants	2X/day infloran until D/C (L acidophilus, B. infantis)	1% versus 5.3%
Bin-Nun et al. [63]	Israel VLBW < 1500 g prospective, masked randomized control trial singal site-145 infants	Daily Abc Dophilus until 36 wks postconceptual age (B. infantis, Strep thermophilus, B. Bifidus)	1% versus 14%
Lin et al. [64]	Taiwan VLBW < 1500 g prospective, masked randomized control trial multicentre-434 infants	2X/day infloran until D/C (L acidophilus, B. infantis)	1.8% versus 6.5%