Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 11

Forest plot (meta-analysis, random effect model) indicating the cumulative effect sizes for percentage of sites with probing depth reduction at sites with severe periodontitis (≥7 mm).

Percentage of sites with PD reduction at sites with severe periodontitis (≥7 mm)						Std diff in means and 95% CI
Study	Antibiotic	Placebo	Std diff in means; 95% Cl	Z value	𝑃 value
Caton et al., 2000 [10]	90	93	0.244	1.647	0.100
Preshaw et al., 2004 [12]	10	10	0.160	1.152	0.249
Novak et al., 2002 [11]	107	102	1.296	2.634	0.008
Mohammad et al., 2005 [8]	66	76	0.530	3.096	0.002
Guerrero et al., 2005 [14]	20	21	0.787	2.426	0.015
Griffitz et al., 2011 [17]	20	21	0.526	1.656	0.098
Synthesis	313	323	0.358	4.460	0.000

PD: probing depth, 𝑃<0.05, confidence level 95%.