International Scholarly Research Notices

Research Article

Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 3

Clinical outcomes reported in randomized controlled trials evaluating the efficacy of adjunctive antibiotic treatment in SRP.


					CAL gain		Sites with PD reduction		% Sites with CAL gain		% Sites with PD reduction
Authors	Periodontal disease	Study duration	Study groups		4–6 mm	≥7 mm	4–6 mm	≥7 mm	4–6 mm	≥7 mm	4–6 mm	≥7 mm

(1) Caton et al. [10]	Chronic periodontitis	9 months	SRP + SDD	90	1.03	1.55	0.95	1.68		22	47	22
(1) Caton et al. [10]	Chronic periodontitis	9 months	SRP + placebo	93	0.86	1.17	0.69	1.29	38	16	35	13
(2) Golub et al. [7]	Chronic periodontitis	33 weeks	SRP + SDD	27	−0.15
(2) Golub et al. [7]	Chronic periodontitis	33 weeks	SRP + placebo	39	−0.8
(3) Novak et al. [11]	Generalized severe periodontitis	9 months	SRP + SDD	10	1	1.78	1.2	3.02	29	15	48	26
(3) Novak et al. [11]	Generalized severe periodontitis	9 months	SRP + placebo	10	0.56	1.24	0.97	1.42	21	11	21	6
(4) Preshaw et al. [12]	Chronic periodontitis	9 months	SRP + SDD	107	1.27	2.09	1.29	2.3	58	33	.2	37
(4) Preshaw et al. [12]	Chronic periodontitis	9 months	SRP + placebo	102	0.94	1 .6	0.96	1.71	44	20	.5	21
(5) Mohammad et al., [8]	Chronic periodontitis	9 months	SRP + SDD	66	1.29	2.12	1.33	2.35	63	37	66	42
(5) Mohammad et al., [8]	Chronic periodontitis	9 months	SRP + placebo	76	1.01	1.55	1	1.74	45	20	47	22
(6) Guerrero et al. [14]	Aggressive periodontitis	6 months	SRP + AMOXL-METRO	20	0.5	1	0.4	1			30	55
(6) Guerrero et al. [14]	Aggressive periodontitis	6 months	SRP + placebo	21	0.2	0.7	0.1	0.8			21	37
(7) Reinhardt et al. [15]	Chronic periodontitis	24 months	SRP + SDD	64						5	15
(7) Reinhardt et al. [15]	Chronic periodontitis	24 months	SRP + placebo	64						3.4	0
(8) Needleman et al. [16]	Chronic periodontitis	6 months	SRP + SDD	16	0.65	1.4
(8) Needleman et al. [16]	Chronic periodontitis	6 months	SRP + placebo	18	0.4	0.98
(9) Griffiths et al. [17]	Aggressive periodontitis	8 months	SAP + AMOXL-METRO + placebo	20							31	53
(9) Griffiths et al. [17]	Aggressive periodontitis	8 months	SRP + placebo + AMOXL-METRO	21	0.3	0.7	0.4	0.9			27	49

CAL: clinical attachment level; PD: probing depth; SRP: scaling and root planing; SDD: subantimicrobial dose doxycycline, 20 mg/12 hrs; AMOXI-METRO: amoxicillin-metronidazole, 500 mg of each/8 hrs/7 days.
*Tooth sites were stratified according to the degree of disease severity (magnitude of PD) evident at baseline. Tooth sites with a baseline PD of 0 to 3 mm were considered normal, tooth sites with a baseline PD of 4 to 6 mm were considered mildly to moderately diseased; tooth sites with a baseline PD of >7 mm were considered severely diseased.