Preparation of ^99mTc-Clomiphene Citrate as a Novel Agent for Breast Cancer Imaging

Table 1

Biodistribution of ^99mTc-Clomiphene in normal Swiss albino mice at different time intervals after injection.

Organs and body fluids	Percent ID/organ
	Time after injection
	15 min	30 min	1 hr	4 hr	24 hr
Blood	17.8 ± 1.8	18.0 ± 1.2	12.7 ± 1.1	6.5 ± 0.4	3.6 ± 0.2
Kidneys	18.3 ± 0.3	17.7 ± 1.1	15.5 ± 0.7	11.1 ± 1.1	3.1 ± 0.5
Liver	4.2 ± 0.3	3.6 ± 0.1	3.0 ± 0.2	2.1 ± 0.4	0.9 ± 0.2
Spleen	2.0 ± 0.2	3.2 ± 0.4	2.9 ± 0.7	2.3 ± 0.4	1.8 ± 0.7
Intestine	4.9 ± 1.2	5.2 ± 1.4	6.4 ± 1.5	6.4 ± 0.9	7.4 ± 0.5
Stomach	7.1 ± 0.6	10.3 ± 1.3	13.1 ± 1.0	11.7 ± 1.2	8.3 ± 0.5
Lungs	5.5 ± 0.1	3.3 ± 0.7	2.9 ± 0.5	2.4 ± 0.4	1.1 ± 0.4
Heart	12.0 ± 0.6	7.0 ± 0.7	3.5 ± 0.6	3.4 ± 0.4	1.5 ± 0.1
Thyroid	0.3 ± 0.03	0.9 ± 0.2	0.9 ± 0.3	1.4 ± 0.2	0.7 ± 0.3
Muscle	0.9 ± 0.2	2.0 ± 0.5	2.7 ± 0.7	3.3 ± 0.3	2.6 ± 0.1
Bone	0.6 ± 0.1	0.7 ± 0.3	1.2 ± 0.1	1.4 ± 0.3	2.0 ± 0.4

ID/gram ± S.D, n = 6.