Research Article
Preparation of 99mTc-Clomiphene Citrate as a Novel Agent for Breast Cancer Imaging
Table 3
Biodistribution of
99mTc-Clomiphene in Swiss albino solid tumor bearing mice at different time intervals after injection.
| | Organs and body fluids | Percent ID/organ | | Time after injection | 15 min
| 30 min | 1 hr | 4 hr | 24 hr |
| | Blood | 16.8 ± 1.8 | 13.8 ± 0.9 | 6.4 ± 1.1 | 3.2 ± 0.5 | 2.3 ± 0.7 | | Kidneys | 18.9 ± 0.9 | 18.2 ± 0.9 | 13.8 ± 1.3 | 9.1 ± 1.3 | 3.8 ± 0.7 | | Liver | 4.4 ± 0.27 | 3.2 ± 0.1 | 3.5 ± 0.1 | 3.3 ± 0.4 | 2.1 ± 0.1 | | Spleen | 1.7 ± 0.1 | 1.8 ± 0.4 | 2.1 ± 0.7 | 1.6 ± 0.25 | 1.2 ± 0.4 | | Intestine | 5.2 ± 0.2 | 5.2 ± 1.3 | 6.9 ± 1.2 | 7.2 ± 0.9 | 7.5 ± 0.5 | | Stomach | 8.1 ± 0.6 | 9.8 ± 1.2 | 11.8 ± 0.5 | 12.3 ± 1.1 | 5.5 ± 1.2 | | Lungs | 5.5 ± 0.1 | 3.3 ± 0.5 | 1.9 ± 0.4 | 1.7 ± 0.7 | 1.9 ± 0.6 | | Heart | 7.0 ± 0.8 | 4.5 ± 1.5 | 2.5 ± 0.7 | 2.2 ± 0.7 | 1.1 ± 0.4 | | Thyroid | 0.8 ± 0.02 | 1.2 ± 0.4 | 1.3 ± 0.7 | 1.7 ± 0.23 | 0.6 ± 0.3 | | Normal muscle | 0.8 ± 0.05 | 2.9 ± 0.6 | 2.3 ± 0.6 | 3.1 ± 0.9 | 2.9 ± 0.5 | | Bone | 1.2 ± 0.1 | 1.6 ± 0.5 | 1.4 ± 0.7 | 1.2 ± 0.4 | 0.7 ± 0.5 | | Tumor muscle | 2.7 ± 0.2 | 5.6 ± 0.9 | 12.5 ± 1.8 | 8.8 ± 1.1 | 4.2 ± 0.9 |
|
|
% ID/gram ± S.D, n = 6.
|
