Models, Regulations, and Functions of Microtubule Severing by Katanin

Figure 6

Role of Katanin in neuron development. In neuron cell body, Katanin severs longer microtubules to generate shorter microtubules which can be easily transported to axons with the help of motor proteins to help axon outgrowth and target reaching. In axons, binding of NAP and Tau proteins to shorter microtubules prevent further activity of Katanin in axonal microtubules.