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Research Article

The Global Transcriptional Response of Isolated Human Islets of Langerhans to Glucagon-Like Peptide-1 Receptor Agonist Liraglutide

Table 2

(a) Upregulated genes selected from GLP-1 treated islet, (b) Downregulated genes selected from GLP-1 treated islet.

(a)


Symbol	Name	Chromosome location	FC	(-test)

	Homo sapiens cDNA FLJ39067 fis, clone NT2RP7014910.		3.240	0.027
SEM A3C	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	7q21-q31	3.172	0.031
RBBP6	Retinoblastoma binding protein 6	16p 12-p11.2	3.147	0.032
BARX1	BarH-like homeobox 1	9q12	3.122	0.020
S100A9	S100 calcium binding protein A9 (calgranulin B)	1q21	2.940	0.006
DNAM-1	Adhesion glycoprotein	18q22.3	2.935	0.007
	Homo sapiens cDNA FLJ14046 fis, clone HEMBA1006461.		2.907	0.006
	Homo sapiens cDNA FLJ10906 fis, clone OVARC1000035.		2.829	0.016
SEC15B	Sec15B protein	2p12	2.776	0.026
HIST1H3I	Histone 1, H3i	6p22-p21.3	2.773	0.001
PRLR	Prolactin receptor	5p14-p13	2.698	0.039
CYLD	Cylindromatosis (turban tumor syndrome)	16q11.2	2.672	0.031
SULT1C1	Sulfotransferase family, cytosolic, 1C, member 1	2q11.1-q11.2	2.586	0.034
	Homo sapiens, clone IMAGE: 4702418, mRNA		2.522	0.016
PTPN7	Protein tyrosine phosphatase, non-receptor type 7	1q32.1	2.504	0.017
CCL3	Chemokine (C–C motif) ligand 3	17q11-q21	2.500	0.000
S100A4	S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)	1q21	2.398	0.026
	Homo sapiens, clone IMAGE: 4471726, mRNA		2.364	0.020
KIAA1076	KIAA1076 protein	12q24.31	2.310	0.020
APOBEC3G	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	22q13.1-q13.2	2.301	0.043
TRPM3	Transient receptor potential cation channel, subfamily M, member 3	9q21.11	2.265	0.027
	Homo sapiens mRNA; cDNA DKFZp434E2423 (from clone DKFZp434E2423)		2.225	0.040
PNUTL2	Peanut-like 2 (Drosophila)	17q22-q23	2.201	0.020
CSPG2	Chondroitin sulfate proteoglycan 2 (versican)	5q14.3	2.198	0.037
COL14A1	Collagen, type XIV, alpha 1 (undulin)	8q23	2.189	0.025
MGC27165	Hypothetical protein MGC27165	14	2.111	0.021
C16orf5	Chromosome 16 open reading frame 5	16p13.3	2.106	0.016
FLJ23342	Hypothetical protein FLJ23342	11q24.2	2.089	0.024
SBBI31	SBBI31 protein	5q23.2	2.085	0.029
PAX4	Paired box gene 4	7q32	2.082	0.040
FLJ10140	Hypothetical protein FLJ10140	22q13	2.077	0.029
KIAA0999	KIAA0999 protein	11q23.3	2.048	0.015
	Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 362780.		2.008	0.036

(b)


Symbol	Name	Chromosome location	FC	(- test)

GAS2	Growth arrest-specific 2	11p14.3-15.2	0.498	0.045
SUOX	Sulfite oxidase	12q13.13	0.496	0.034
KIAA0469	KIAA0469 gene product	1p36.23	0.496	0.026
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	7q36.3	0.495	0.022
RBM 9	RNA binding motif protein 9	22q13.1	0.490	0.034
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	6q22-q23	0.488	0.030
CLASP2	Cytoplasmic linker associated protein 2	3p 22.2	0.487	0.047
MGC5297	Hypothetical protein M GC5297	5p15.3-p15.2	0.486	0.039
PPP2R4	Protein phosphatase 2A, regulatory subunit B′ (PR 53)	9q34	0.484	0.031
PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	19p13.3	0.482	0.022
ZFHX1B	Zinc finger homeobox 1b	2q22	0.479	0.028
ADCY9	Adenylate cyclase 9	16p13.3	0.463	0.043
FLJ12788	Hypothetical protein FLJ12788	2p12	0.458	0.015
TM 6SF1	Trans membrane 6 superfamily member 1	15q24-q26	0.447	0.043
TBCE	Tubulin-specific chaperone e	1q42.3	0.446	0.035
GTF2H2	General transcription factor IIH, polypeptide 2, 44k Da	5q12.2-q13.3	0.438	0.007
PRO1331	Hypothetical protein PRO1331	5q33.3	0.437	0.024
ZNF185	Zinc finger protein 185 (LIM domain)	Xq28	0.428	0.021
KIAA0460	KIAA0460 protein	1q21.2	0.427	0.021
DKFZP434B168	DKFZP434B168 protein	1p36.13-q42.3	0.426	0.042
FCMD	Fukuyama type congenital muscular dystrophy (fukutin)	9q31-q33	0.415	0.045
ABCF2	ATP-binding cassette, subfamily F (GCN20), member 2	7q36	0.414	0.012
LM O7	LIM domain only 7	13q21.33	0.413	0.039
SULF1	Sulfatase 1	8q13.1	0.412	0.033
KIAA0090	KIAA0090 protein	1p36.13	0.411	0.003
POR	P450 (cytochrome) oxidoreductase	7q11.2	0.407	0.015
SE70-2	Cutaneous T-cell lymphoma tumor antigen se70-2	13q22.1	0.406	0.030
NKX6-1	NK6 transcription factor related, locus 1 (Drosophila)	4q21.2-q22	0.403	0.006
LOC51231	VRK3 for vaccinia related kinase 3	19q13	0.403	0.002
BYSL	Bystin-like	6p21.1	0.401	0.032
HIP1R	Huntingtin interacting protein-1-related	12q24	0.396	0.012
PPP2R4	Protein phosphatase 2A, regulatory subunit B′ (PR 53)	9q34	0.387	0.046
WASL	Wiskott-Aldrich syndrome-like	7q31.3	0.383	0.032
TIMM 17A	Translocase of inner mitochondrial membrane 17 homolog A (yeast)	1q32.1	0.378	0.032
ARL4	ADP-ribosylation factor-like 4	7p21-p15.3	0.375	0.002
LOC51204	Clone HQ0477 PRO0477p	17q24.1	0.363	0.023
KIAA1023	KIAA1023 protein	7p22.3	0.357	0.017
CPT1A	carnitine palmitoyl transferase 1A (liver)	11q13.1-q13.2	0.351	0.021
RAD51C	RAD51 homolog C (S. cerevisiae)	17q22-q23	0.347	0.022
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	17q21.32	0.345	0.008
MGC4309	hypothetical protein M GC4309	1q32.1	0.336	0.007
	ESTs, weakly similar to neuronal thread protein (Homo sapiens)		0.334	0.030
KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	21q22.2	0.306	0.006
UTS2	urotensin 2	1p36	0.299	0.032
SLC7A6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6	16q22.1	0.260	0.016
HSA9947	putative ATPase	1p36	0.231	0.050
ARHGEF9	Cdc42 guanine nucleotide exchange factor (GEF) 9	Xq11.1	0.169	0.019