Designing Paclitaxel Drug Delivery Systems Aimed at Improved Patient Outcomes: Current Status and Challenges
Figure 8
(a) Paclitaxel release at 4°C from 2′-PEG-paclitaxel (circles), 2′-succinyl-paclitaxel (triangles pointing up) and 2′-MPA-paclitaxel (triangles pointing down) in PBS buffer pH 5.8, 2′-PEG-paclitaxel (squares), 2′-succinyl-paclitaxel (triangles pointing up) and 2′-MPA-paclitaxel (triangles pointing down) in PBS buffer pH 7.4 (reproduced with permission from Ceruti et al., [52]). (b) Paclitaxel release at 37°C from 2′-PEG-paclitaxel (circles), 2′-succinyl-paclitaxel (triangles pointing down) and 2′-MPA-paclitaxel (hexagons) in PBS buffer pH 7.4, 2′-PEG-paclitaxel (squares), 2′-succinyl-paclitaxel (triangles pointing up) and 2′-MPA-paclitaxel (diamonds) in PBS buffer pH 5.8 (reproduced with permission from Ceruti et al., [52]).
