Study on Genetic Variance of miR-541 in Type 1 Diabetes

Figure 3

Luciferase reporter assay of −780∼+187 region of miR-541. In contrast to PGL3 BASIC control vector, the constructed plasmid containing −780bp∼+167 regions had promoter activity, indicating a putative promoter of miR-541 in this region. However, there is no significant difference in promoter activity between wildtype and -404 G→T mutation construct. 𝑃<0.05 compared with PGL3 BASIC control.