The Evolution of Methotrexate as a Treatment for Ectopic Pregnancy and Gestational Trophoblastic Neoplasia: A Review

Figure 1

The mechanism by which methotrexate inhibits cellular proliferation. Active transporter includes the reduced folate carrier and an endocytic pathway activated by a folate receptor; dUMP: deoxyuridine monophosphate; CH₂FH₄: methylenetetrahydrofolate.