The Evolution of Methotrexate as a Treatment for Ectopic Pregnancy and Gestational Trophoblastic Neoplasia: A Review

Table 1

Modified WHO prognostic scoring system as adapted by FIGO [30].

Scores	0	1	2	4
Age	<40	>40	—	—
Antecedent pregnancy	Mole	Miscarriage	Term	—
Interval months from index pregnancy	<4	4–6	7–12	>12
Pretreatment serum βhCG (IU/L)	<10^3	10^3–10^4	10^4–10^5	>10^5
Largest tumour size (including uterus) (cm)	<3	3-4	≥5	—
Site of metastases	Lung	Spleen/kidney	Gastrointestinal	Liver/brain
Number of metastases	—	1–4	5–8	>8
Previous failed chemotherapy	—	—	Single drug	≥2 drugs