External Validation of an Artificial Neural Network and Two Nomograms for Prostate Cancer Detection
Table 2
Mean and median values with ranges for age, tPSA, %fPSA, prostate volume, PSAD, and number of positive (suspicious) DREs in all, PCa, and NEM patients for both cohorts.
Variable
External validation cohort
“ProstataClass” cohort+
P value
All
PCa
NEM
All
PCa
NEM
Age (years)
Mean
66
67
67
64
63
66
Median
67*
68*
66*
64
63
66
<0.0005
Range
46–83
50–82
46–83
38–85
43–79
38–85
tPSA (ng/mL)
Mean
6.84
6.83
6.85
7.54
8.77
5.81
Median
6.66
6.66
6.79
6.63
7.75
4.69
0.387
Range
4.01–9.99
4.01–9.61
4.06–9.99
0.49–27.04
0.86–24.02
0.49–27.04
%fPSA (%)
Mean
15.67
13.14
17.1
14.84
11.30
19.86
Median
15.0*
12.0*
16.0*
12.75
10.27
18.31
0.002
Range
4.0–48.0
5.0–30.0
4.0–48.0
2.52–69.39
3.10–49.86
2.52–69.39
Volume (mL)
Mean
42.62
34.14
47.35
43.7
37.2
52.9
Median
37.65
29.9
43.8
38
34
45.5
0.900
Range
7.1–171
7.1–100
15–171
10–180
10–110
13–180
PSAD (tPSA/Vol.)
Mean
0.197
0.242
0.172
0.211
0.276
0.120
Median
0.174
0.221
0.154
0.157
0.224
0.086
0.030
Range
0.04–0.80
0.05–0.80
0.04–0.55
0.01–1.35
0.03–1.35
0.01–1.00
No. pos. DRE (%)
67 (23.8%)*
37 (36.6%)*
30 (16.6%)*
314 (39.3%)
284 (60.7%)
30 (9.1%)
<0.0005
PSA and %fPSA of “ProstataClass” cohort using the Beckman Access assay.
*Significantly different from “ProstataClass” cohort.