What Have We Learned about the Pathogenesis of Rheumatoid Arthritis from TNF-Targeted Therapy?
Figure 3
Joint damage in hTNFα-transgenic mice. Top: erosive changes in the cartilage-bone-pannus region of a proximal interphalangeal joint from a hTNFα-transgenic mouse with arthritis. Note the focal erosion of subchondral bone. Bottom: normal joint from a non-transgenic littermate. Haematoxylin and eosin.
