Method Development and Validation of Darifenacin in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study

Table 2

Precision and accuracy (analysis with spiked plasma samples at four different concentrations).

Spiked plasma concentration; (pg/mL)	Within-run 𝑛=6		Between-run 𝑛=36
	Accuracy; (Mean ± S.D.)	Precision; (CV%)	Accuracy; (Mean ± S.D.)	Precision; (CV%)
10.00	11.14±0.77	6.87	10.79±0.56	5.19
30.00	29.93±0.93	3.10	29.81±0.99	3.32
9000.00	9042.49±167.97	1.86	9090.34±289.83	3.19
18000.00	18457.37±253.95	1.38	18125.79±674.07	3.72