Polymorphic Forms of Lamivudine: Characterization, Estimation of Transition Temperature, and Stability Studies by Thermodynamic and Spectroscopic Studies

Table 3

Enthalpy of solution and solubility of Form I, Form II_L, Form II_H, Form III_L, and Form III_H of lamivudine.

Sample	Enthalpy of solution		Solubility
	(kJ/mol)		(×10^−1 moles/L)
	25°C	37°C	25°C	37°C
Form IL	17.72	18.73	0.42	0.46
Form IH	18.22	19.45	0.39	0.41
Form II	18.83	19.90	0.38	0.40
Form IIIL	12.87	14.99	0.58	0.61
Form IIIH	14.13	16.12	0.48	0.52