Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form

Table 2

Summary of validation parameters.

Parameters	IBU	FAM
Retention time (min)	4.9	6.8
Detection limit (μg/mL)	0.65	0.033
Quantitation limit (μg/mL)	2	0.1
Accuracy (%)	97.60–100.42%	99.85–101.47%
Precision (RSD^a, %)
Intraday precision (𝑛=3)	0.75–0.93%	0.72–0.94%
Interday precision (𝑛=3)	1.02=1.53%	0.92–1.51%
Instrument precision (RSD^a)	0.58%	0.47%

^aRSD is relative standard deviation, and ‘‘𝑛’’ is number of determinations.