Molecular Determinants of Ca_v1.2 Calcium Channel Inactivation

Figure 4

Differential role of the carboxyl- and amino-terminal tails of α _1C in Ca_v1.2 inactivation. Shown are (a) epifluorescent images illustrating the plasma membrane targeting of the EYFP-labeled α _1C (scaling bars, 4 μm) and (b) superimposed traces of the maximum 𝐼_Ba (black) and 𝐼_Ca (red) scaled to the same amplitude for α _1C-PH_C/β _1a/α ₂δ [21, 47], (A) PH_N-α _1C/α ₂δ (B) [47], and Δ_N-α _1C/α ₂δ (C) [47].