Constrained Peptides as Miniature Protein Structures

Table 1

Sequences of constrained human parathyroid hormone peptides.

Peptide	EC50 (nM)
hPTH-(1-31)NH2 (1)	19.9
[Leu^27]cyclo(Glu^22-Lys^26)-hPTH-(1-31)-NH2 (2)	3.3
cyclo(Lys^18-Asp^22)[Ala^1, Nle^8, Lys^18, Asp^22, Leu^27]hPTH(1-31)NH2 (3)	0.29
bicyclo(Lys^18-Asp^22, Lys^26-Asp^30)[Ala^1, Nle^8, Lys^18, Asp^22, Leu^27]hPTH(1-31)NH2 (4)	0.13
tricyclo(Lys^13-Asp^17, Lys^18-Asp^22, Lys^26-Asp^30)[Ala^1, Nle^8, Lys^18, Asp^17,22, Leu^27]hPTH(1-31)NH2  (5)	0.14
[Nle^8,18, Nal^23, Tyr^34]bPTH(1-34)-NH2 (6)	0.85
[Nle^8,18, Aib^12,13, Nal^23, Tyr^34]bPTH(1-34)-NH^2 (7)	0.2