702858.fig.001a
(a)
702858.fig.001b
(b)
Figure 1: Analysis of C1 inhibition in the IR model of inflammatory tissue injury. H&E-stained transverse intestinal sections from inhibition studies were evaluated. (a) Graphical representation of the injury scores form the C1 esterase inhibition studies are shown. By one-way ANOVA testing, specifically the Kruskal-Wallis test, indicated significance between groups in both the B6.MRL/lpr group ( 𝑃 < 0 . 0 0 0 5 ) and the C57Bl/6 group ( 𝑃 < 0 . 0 0 1 ). Subsequent analysis between groups within each strain with Dunn’s multiple-comparison test indicated that there is a significant difference between the sham and IR group but not the sham and C1 inhibition group. Analysis is performed on five animals per treatment group. (b) H&E images illustrate the representative injury level detected in each group.