The Toxic Effects of Polychemotherapy onto the Liver Are Accelerated by the Upregulated MDR of Lymphosarcoma

Table 1

Morphometric analysis of liver tissue of mice with RLS₄₀ subjected to the treatment under Scheme  1.

Passage number	Hepatocyte degeneration, Vv, % (Mean ± SEM)			Hepatocyte necrosis, Vv, % (Mean ± SEM)
	Healthy subjected to CHOP (𝑛=10)	RLS40 without treatment (𝑛=15)	RLS40 subjected to CHOP (𝑛=15)	Healthy subjected to CHOP (𝑛=10)	RLS40 without treatment (𝑛=15)	RLS40 subjected to CHOP (𝑛=15)
Baseline*	7.3±0.7	11.4±0.7		3.1±0.5	7.6±0.7
1^†	15.7±0.9	16.1±0.8	21.9±0.7^#	12.6±1	19.1±1.0	23.1±0.8^#
2^‡	17.1±1.0	22.2±1.2^∧	18.8±0.7^#∧	10.0±0.8	25.1±0.9^∧	25.9±0.9
3^‡	15.4±1.0	16.2±0.6	15.1±0.7^∧	12.0±0.8	29.7±1.0^∧	27.7±0.9^∧
4^‡	16.0±1.2	17±0.8	15.5±0.9^∧	13.2±1.2	33.8±1.3^∧	30.6±1.0^#∧

*Initial level determined just before treatment (6th day after tumor transplantation).
^†At day 7 after the treatment.
^‡At day 10 after the treatment.
^∧𝑃≤0.05 compared to the 1st passage within one group.
^#𝑃≤0.05 compared to the group without treatment.