The Toxic Effects of Polychemotherapy onto the Liver Are Accelerated by the Upregulated MDR of Lymphosarcoma

Table 2

Morphometric analysis of liver tissue in healthy mice and mice with RLS₄₀ after the treatment under Scheme  2.

PCHT courses, number	Days after treatment	Hepatocyte degeneration, Vv, % (Mean ± SEM)		Hepatocyte necrosis, Vv, % (Mean ± SEM)		Volume density of hepatic lymphoma infiltration, Vv, %
		Healthy mice	Mice with RLS40	Healthy mice	Mice with RLS40
		(𝑛=45)	(𝑛=45)	(𝑛=45)	(𝑛=45)
Baseline^#		7.3±0.7	12.6±1^∗	3.1±0.5	12.1 ± 1*	—
1	1	33.7±2.2	40.7±3.2	17.1±1.1	13.5±1.2^∗	—
	3	24±2.1	20.6±1.6	16.4±1.4	19.2±1.3	—
	7	15.7±0.9	27.7±1.6^∗	12.6±1	18±1.35^∗	15±4
2	1	27.5±1.5	25.9±1.2	19.7±1.7	24±1^∗	—
	3	26.6±1.7	40.7±2.1^∗	17.6±1.4	20.8±1.3	—
	7	31.4±1.8	29.6±1.9	17±1	37.9±3.7^∗	26±4
3	1	27.2±1.2	34.3±3^∗	13.6±1.3	40.8±3.6^∗	—
	3	27.9±1.3	36.9±2.6^∗	9.6±0.9	47.7±4.1^∗	30±5
	7	28.7±1.2	—	22.9±1.2	—	—

^∗𝑃≤0.05 compared to healthy mice.
^#Initial level determined just before treatment (6th day after tumor transplantation).