Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations

Table 1

Optical characteristics and precision.

Parameter	Method A	Method B	Method C
𝜆max nm	410	440	500
Linear range (μg/mL)	0.5–12	0.5–10	0.3–10
Molarabsorptivity(𝜀), (L/mol/cm)	2.23 × 10^4	2.04 × 10^4	1.35 × 10^4
Sandell sensitivity (μg cm^−2)	0.0281	0.0136	0.0205
Intercept (𝑎)	0.0124	0.0179	0.0116
Slope (𝑏)	0.0734	0.0669	0.0439
Correlation coefficient (𝑟)	0.9988	0.9976	0.9975
𝑆𝑎	0.0182	0.0248	0.0167
𝑆𝑏	0.0012	0.0027	0.0018
LOQ (μg/mL)	0.1197	0.1047	0.2587
LOD (μg/mL)	0.0395	0.0345	0.0854

^*𝑦=𝑏𝑐+𝑎 where 𝑐 is the concentration of flutamide in μg/mL and 𝑦 is the absorbance at the respective 𝜆_max.
𝑆_𝑎 is the standard deviation of intercept, 𝑆_𝑏 is the standard deviation of slope.