Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents

Table 2

Antiviral activity of compounds 6a–6d.

Anti-JEV in vitro					Anti-HSV-1 in vitro
Compound. number	CT50 (𝜇g/mL)	EC50 (𝜇g/mL)	TI	Inhibition (%)	EC50 (𝜇g/mL)	TI	Inhibition (%)
6a	500	125	04	10	250	02	10
6b	500	125	04	10	250	02	10
6c	250	7.8	32	50	125	02	23
6d	500	125	04	15	250	02	20

CT₅₀: 50% cytotoxic concentration; EC₅₀: 50% effective concentration; TI: therapeutic index.