Inhibition of LPS-Induced Activation of Coagulation by p38 MAPK Inhibitor

Figure 2

Clotting time (CT) in whole blood after LPS stimulation with or without preincubation with specific inhibitors. (a) Levels of CT of whole blood under control conditions, in the presence of LPS (100 μg/mL) for 4 hours and after pretreatment with 100 μM BAY117082 (BAY), 100 μM SP600125 (SP), or SB203580 (SB) for 1 hour. Data are presented as mean ± SD. *𝑃<0.05 versus data for LPS. (b) Levels of CT of whole blood under control conditions, in the presence of LPS (100 μg/mL) for 4 hours, and after pretreatment with 1 μM, 10 μM, or 100 μM SB203580 (SB) for 1 hour. Data are presented as means ± SD. *𝑃<0.05 versus data for LPS.

(a)

(b)