About this Journal Submit a Manuscript Table of Contents
ISRN Hematology
Volume 2012 (2012), Article ID 762614, 5 pages
http://dx.doi.org/10.5402/2012/762614
Research Article

Inhibition of LPS-Induced Activation of Coagulation by p38 MAPK Inhibitor

1Division of Neonatology, Department of Paediatrics, Medical School, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
2Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
3Department of Anesthesiology, University of Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen, Germany

Received 5 December 2011; Accepted 27 December 2011

Academic Editors: L. Bordin and K. Oritani

Copyright © 2012 Lutz Koch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Akira and K. Takeda, “Toll-like receptor signalling,” Nature Reviews Immunology, vol. 4, no. 7, pp. 499–511, 2004. View at Scopus
  2. B. A. Beutler, “TLRs and innate immunity,” Blood, vol. 113, no. 7, pp. 1399–1407, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. E. M. Pålsson-McDermott and L. A. J. O'Neill, “Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4,” Immunology, vol. 113, no. 2, pp. 153–162, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. R. S. Hotchkiss, P. E. Swanson, B. D. Freeman et al., “Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction,” Critical Care Medicine, vol. 27, no. 7, pp. 1230–1251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Levi and H. Ten Cate, “Disseminated intravascular coagulation,” The New England Journal of Medicine, vol. 341, no. 8, pp. 586–592, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Ohsawa, T. Koyama, N. Nara, and S. Hirosawa, “Induction of tissue factor expression in human monocytic cells by protease inhibitors through activating activator protein-1 (AP-1) with phosphorylation of Jun-N-terminal kinase and p38,” Thrombosis Research, vol. 112, no. 5-6, pp. 313–320, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. N. Mackman, “Regulation of the tissue factor gene,” Thrombosis and Haemostasis, vol. 78, no. 1, pp. 747–754, 1997. View at Scopus
  8. L. Koch, S. Hofer, M. A. Weigand, D. Frommhold, and J. Poeschl, “Lipopolysaccharide-induced activation of coagulation in neonatal cord and adult blood monitored by thrombelastography,” Thrombosis Research, vol. 124, no. 4, pp. 463–467, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. M. T. Ganter and C. K. Hofer, “Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices,” Anesthesia and Analgesia, vol. 106, no. 5, pp. 1366–1375, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. L. Koch, B. Fritzsching, D. Frommhold, and J. Poeschl, “Lipopolysaccharide-induced expression of Th1/Th2 cytokines in whole neonatal cord and adult blood: role of nuclear factor-kappa B and p38 MAPK,” Neonatology, vol. 99, no. 2, pp. 140–145, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. S. V. Mallett and D. J. A. Cox, “Thrombelastography,” British Journal of Anaesthesia, vol. 69, no. 3, pp. 307–313, 1992. View at Scopus
  12. M. Hartmann, S. Özlügedik, and J. Peters, “Thiopental inhibits lipopolysaccharide-induced tissue factor expression,” Anesthesia and Analgesia, vol. 109, no. 1, pp. 109–113, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. K. Zacharowski, C. Sucker, P. Zacharowski, and M. Hartmann, “Thrombelastography for the monitoring of lipopolysaccharide induced activation of coagulation,” Thrombosis and Haemostasis, vol. 95, no. 3, pp. 557–561, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. E. L. R. Swennen, A. Bast, and P. C. Dagnelie, “Immunoregulatory effects of adenosine 5′-triphosphate on cytokine release from stimulated whole blood,” European Journal of Immunology, vol. 35, no. 3, pp. 852–858, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. A. Nooteboom, G. J. Van der Linden, and T. Hendriks, “Tumor necrosis factor-α and interleukin-1β mediate endothelial permeability induced by lipopolysaccharide-stimulated whole blood,” Critical Care Medicine, vol. 30, no. 9, pp. 2063–2068, 2002. View at Scopus
  16. M. S. Dehoux, S. Hernot, K. Asehnoune et al., “Cardiopulmonary bypass decreases cytokine production in lipopolysaccharide-stimulated whole blood cells: roles of interleukin-10 and the extracorporeal circuit,” Critical Care Medicine, vol. 28, no. 6, pp. 1721–1727, 2000. View at Scopus
  17. J. M. B. Pöschl, C. Leray, P. Ruef, J. P. Cazenave, and O. Linderkamp, “Endotoxin binding to erythrocyte membrane and erythrocyte deformability in human sepsis and in vitro,” Critical Care Medicine, vol. 31, no. 3, pp. 924–928, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. J. Kraatz, L. Clair, J. L. Rodriguez, and M. A. West, “Macrophage TNF secretion in endotoxin tolerance: role of SAPK, p38, and MAPK,” Journal of Surgical Research, vol. 83, no. 2, pp. 158–164, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. B. D. Shames, C. H. Selzman, E. J. Pulido et al., “LPS-induced NF-κB activation and TNF-α release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent,” Journal of Surgical Research, vol. 83, no. 1, pp. 69–74, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. E. De Jonge, P. E. P. Dekkers, A. A. Creasey et al., “Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia,” Blood, vol. 95, no. 4, pp. 1124–1129, 2000. View at Scopus
  21. M. Levi, H. Ten Cate, K. A. Bauer et al., “Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees,” Journal of Clinical Investigation, vol. 93, no. 1, pp. 114–120, 1994. View at Scopus
  22. A. J. Chu, Z. G. Wang, M. A. Walton, and A. Seto, “Involvement of MAPK activation in bacterial endotoxin-inducible tissue factor upregulation in human monocytic THP-1 cells,” Journal of Surgical Research, vol. 101, no. 1, pp. 85–90, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. T. Van der Poll, M. Levi, C. E. Hack et al., “Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees,” Journal of Experimental Medicine, vol. 179, no. 4, pp. 1253–1259, 1994. View at Scopus
  24. C. T. Esmon, “The impact of the inflammatory response on coagulation,” Thrombosis Research, vol. 114, no. 5-6, pp. 321–327, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. J. Branger, B. Van Den Blink, S. Weijer et al., “Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia,” Journal of Immunology, vol. 168, no. 8, pp. 4070–4077, 2002. View at Scopus
  26. J. Hambleton, S. L. Weinstein, L. Lem, and A. L. Defranco, “Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 7, pp. 2774–2778, 1996. View at Scopus
  27. M. Karin, Z. G. Liu, and E. Zandi, “AP-1 function and regulation,” Current Opinion in Cell Biology, vol. 9, no. 2, pp. 240–246, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Olsnes, J. Olofsson, and H. J. Aarstad, “MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-α secretion following OK-432 in vitro stimulation of purified human monocytes,” Scandinavian Journal of Immunology, vol. 74, pp. 114–125, 2011.
  29. J. Branger, B. Van den Blink, S. Weijer et al., “Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia,” Blood, vol. 101, no. 11, pp. 4446–4448, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus