Impact of Salmonella enterica Type III Secretion System Effectors on the Eukaryotic Host Cell

Figure 2

T3SS1-dependent invasion of eukaryotic cells. Salmonella triggers its own internalization into host cells using a mechanism characterized by the appearance of large membrane ruffles at the bacterial entry site. Bacterial effector proteins SipA, SipC, SopB, SopE, and SopE2, which are injected into host cells through T3SS1, induce this process. Actin remodeling, mediated by host factors represented in yellow, and membrane fusion, mediated by host factors represented in brown, are involved in the mechanism of internalization. The process is reverted by the effector SptP.