Impact of Salmonella enterica Type III Secretion System Effectors on the Eukaryotic Host Cell

Figure 4

Biogenesis of the Salmonella-containing vacuole. After internalization, Salmonella establishes an intracellular niche inside a modified phagosome known as Salmonella-containing vacuole (SCV). The initial step in SCV biogenesis (0-1 h) is governed by T3SS1 effectors (in blue) SopB and SptP and is characterized by the formation of SVATs and SNX3 tubules. The movement of the SCV to a juxtanuclear position during the intermediate stage of development (1–4 h) requires the participation of the T3SS1 effectors SipA and SopB and the T3SS2 effectors (in red) SifA, SseF, and SseG. Many effectors are involved in the final stage of maturation and in the maintenance of the SCV. Replication is initiated 4–6 h postinvasion and is accompanied by the formation of different kinds of tubules known as SIFs, SISTs, and LNTs. Effectors involved in the formation of these tubules are depicted in red (T3SS2 effectors) and in purple (effectors of both systems). The maturation process is also characterized by the interaction with the host endocytic and secretory pathways.