Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre

Table 3

Clinical blood chemistry values of female rats in chronic toxicity of ZA extract.

	Control	ZA extract
		1 g/kg	2 g/kg	4 g/kg	8 g/kg^a	8 g/kg^b
Glucose (mg/dL)	104.90±4.94	100.40±3.77	97.70±2.94	98.00±4.28	99.90±6.25	103.50±6.26
BUN (mg/dL)	18.90±0.90	18.80±0.99	19.30±0.63	17.10±0.96	17.00±0.61	19.50±0.70
Creatinine (mg/dL)	0.34±0.02	0.35±0.02	0.31±0.01	0.31±0.01	0.33±0.01	0.39±0.02
Total protein (g/dL)	5.15±0.09	5.23±0.17	5.19±0.09	5.18±0.05	5.21±0.10	5.60±0.10 *
Albumin (g/dL)	2.80±0.07	2.74±0.09	2.67±0.05	2.72±0.05	2.72±0.06	2.98±0.08
Total bilirubin (mg/dL)	0.12±0.01	0.19±0.04	0.19±0.06	0.10±0.00	0.13±0.02	0.21±0.03
Direct bilirubin (mg/dL)	0.05±0.03	0.12±0.06	0.13±0.07	0.02±0.01	0.07±0.03	0.17±0.04
SGOT (U/l)	145.00±13.32	136.80±11.21	148.50±8.52	121.10±12.80	160.70±21.23	182.90±16.92
SGPT (U/l)	49.00±8.48	35.20±1.44	43.30±6.04	34.20±3.52	43.90±10.82	47.10±5.38
ALP (U/l)	33.40±1.33	36.00±2.44	33.60±1.98	36.20±1.40	35.90±2.15	31.80±1.83

Values are expressed as mean ± SEM, 𝑛=10.
*Significantly different from control, 𝑃<0.05.
^aA group was given ZA extract at 8 g/kg daily over 180 days.
^bA satellite group was given ZA extract at 8 g/kg daily over 180 days followed by no treatment for 28 days.