Predictors of Conversion to Multiple Sclerosis in Patients with Clinical Isolated Syndrome Using the 2010 Revised McDonald Criteria

Table 2

Clinical and radiological predictors of CIS conversion to MS after 2 years.

Demographic data	CIS cohort	MS cohort	P value
	(𝑛=39)	(𝑛=58)
Sex
Female	21 (21.6%)	34 (35.1%)	0.4
Male	18 (18.6%)	24 (24.7%)	0.08
Age (mean ± SD)	30.21 ± 6.70	24.64 ± 6.77	0.01*
Age
<30 years	18 (18.6%)	45 (46.4%)	0.002*
≥30	21 (21.6%)	13 (13.4%)	0.23
Age at onset (mean ± SD)	25.59 ± 6.89	21.62 ± 6.15	0.01*
Age at onset
<30 years	24 (24.7%)	49 (50.5%)	0.01*
≥30	15 (15.5%)	9 (9.3%)	0.2
Clinical presentation
Optic nerve	6 (6.2%)	11 (11.3%)	0.4
Brainstem/cerebellum	8 (8.2%)	15 (15.5%)	0.4
Spinal cord	11 (11.3%)	19 (19.3%)	0.5
Supratentorial	13 (13.4%)	18 (18.6%)	0.4
Number of lesions in MRI
No lesion	(2.1%)	0 (0%)
1–3 lesions	16 (16.5%)	2 (3.4%)	0.001*
4–8 lesions	16 (16.5%)	21 (21.7%)	0.2
≥9 lesions	5 (5.2%)	35 (36.1%)	0.002*

^*Statistically significant.