Role of Natural Killer Cells in Multiple Sclerosis

Figure 2

Expression of chemokine receptors on the two major subsets of human NK cells. Resting human NK cells are divided into CD56^bright and CD56^dim subsets. The former express CCR4, CCR7, CXCR4, and CX₃CR1, and to a lesser extent CCR1 and CXCR3, whereas the latter cells express CCR4, CXCR4, and CX₃CR1, and to a lesser extent CCR1, CCR7, and CXCR3. Upon activation, the CD56^bright upregulate the expression of CCR1, CCR4, CCR7, CXCR3, CXCR4, and CX₃CR1, whereas CD56^dim cells upregulate the expression of CCR1, CCR2, CCR3, CCR4, CCR6, CCR7, CCR8, CXCR1, CXCR3, CXCR4, and CX₃CR1.