- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2012 (2012), Article ID 797619, 12 pages
A New Strategy to Find Targets for Anticancer Therapy: Chemokine CXCL14/BRAK Is a Multifunctional Tumor Suppressor for Head and Neck Squamous Cell Carcinoma
Oral Health Science Research Center, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka 238-8580, Japan
Received 29 August 2012; Accepted 14 September 2012
Academic Editors: S. L. Halum and S. C. Winter
Copyright © 2012 Ryu-Ichiro Hata. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. Ozawa, Y. Kato, R. Komori, Y. Maehata, E. Kubota, and R. I. Hata, “BRAK/CXCL14 expression suppresses tumor growth in vivo in human oral carcinoma cells,” Biochemical and Biophysical Research Communications, vol. 348, no. 2, pp. 406–412, 2006.
- S. Ozawa, Y. Kato, E. Kubota, and R. I. Hata, “BRAK/CXCL14 expression in oral carcinoma cells completely suppresses tumor cell xenografts in SCID mouse,” Biomedical Research, vol. 30, no. 5, pp. 315–318, 2009.
- S. Ozawa, Y. Kato, S. Ito et al., “Restoration of BRAK/CXCl14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma,” Cancer Science, vol. 100, no. 11, pp. 2202–2209, 2009.
- K. Sato, S. Ozawa, K. Izukuri, Y. Kato, and R. I. Hata, “Expression of tumour-suppressing chemokine BRAK/CXCL14 reduces cell migration rate of HSC-3 tongue carcinoma cells and stimulates attachment to collagen and formation of elongated focal adhesions in vitro,” Cell Biology International, vol. 34, no. 5, pp. 513–522, 2010.
- S. Ito, S. Ozawa, T. Ikoma, N. Yajima, T. Kiyono, and R. I. Hata, “Expression of a chemokine BRAK/CXCL14 in oral floor carcinoma cells reduces the settlement rate of the cells and suppresses their proliferation in vivo,” Biomedical Research, vol. 31, no. 3, pp. 199–206, 2010.
- K. Izukuri, K. Suzuki, N. Yajima et al., “Chemokine CXCL14/BRAK transgenic mice suppress growth of carcinoma cell xenografts,” Transgenic Research, vol. 19, no. 6, pp. 1109–1117, 2010.
- K. D. Hunter, E. K. Parkinson, and P. R. Harrison, “Profiling early head and neck cancer,” Nature Reviews Cancer, vol. 5, no. 2, pp. 127–135, 2005.
- C. R. Leemans, B. J. M. Braakhuis, and R. H. Brakenhoff, “The molecular biology of head and neck cancer,” Nature Reviews Cancer, vol. 11, no. 1, pp. 9–22, 2011.
- D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000.
- B. Vogelstein, E. R. Fearon, S. R. Hamilton et al., “Genetic alterations during colorectal-tumor development,” New England Journal of Medicine, vol. 319, no. 9, pp. 525–532, 1988.
- D. Sidransky, “Emerging molecular markers of cancer,” Nature Reviews Cancer, vol. 2, no. 3, pp. 210–219, 2002.
- R. J. Akhurst, “TGF-β antagonists: why suppress a tumor suppressor?” Journal of Clinical Investigation, vol. 109, no. 12, pp. 1533–1536, 2002.
- P. Benatti, V. Basile, D. Merico, L. I. Fantoni, E. Tagliafico, and C. Imbriano, “A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response,” Nucleic Acids Research, vol. 36, no. 5, pp. 1415–1428, 2008.
- J. M. Roodhart, M. H. Langenberg, E. Witteveen, and E. E. Voest, “The molecular basis of class side effects due to treatment with inhibitors of the VEGF/VEGFR pathway,” Current Clinical Pharmacology, vol. 3, no. 2, pp. 132–143, 2008.
- P. S. Steeg and D. Theodorescu, “Metastasis: a therapeutic target for cancer,” Nature Clinical Practice Oncology, vol. 5, no. 4, pp. 206–219, 2008.
- T. Yoshimura, K. Matsushima, S. Tanaka et al., “Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.,” Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 24, pp. 9233–9237, 1987.
- T. Kakinuma and S. T. Hwang, “Chemokines, chemokine receptors, and cancer metastasis,” Journal of Leukocyte Biology, vol. 79, no. 4, pp. 639–651, 2006.
- D. Raman, P. J. Baugher, Y. M. Thu, and A. Richmond, “Role of chemokines in tumor growth,” Cancer Letters, vol. 256, no. 2, pp. 137–165, 2007.
- D. Raman, P. J. Baugher, Y. M. Thu, and A. Richmond, “Role of Chemokines in Tumor Growth,” Cancer Letters, vol. 256, no. 2, pp. 137–165, 2007.
- A. Zlotnik, O. Yoshie, and H. Nomiyama, “The chemokine and chemokine receptor superfamilies and their molecular evolution,” Genome Biology, vol. 7, no. 12, article 243, 2006.
- S. Meuter and B. Moser, “Constitutive expression of CXCL14 in healthy human and murine epithelial tissues,” Cytokine, vol. 44, no. 2, pp. 248–255, 2008.
- I. Kurth, K. Willimann, P. Schaerli, T. Hunziker, I. Clark-Lewis, and B. Moser, “Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development,” Journal of Experimental Medicine, vol. 194, no. 6, pp. 855–861, 2001.
- P. Schaerli, K. Willimann, L. M. Ebert, A. Walz, and B. Moser, “Cutaneous CXCL14 targets blood precursors to epidermal niches for langerhans cell differentiation,” Immunity, vol. 23, no. 3, pp. 331–342, 2005.
- T. Starnes, K. K. Rasila, M. J. Robertson et al., “The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: implications for the downregulation of CXCL14 in malignancy,” Experimental Hematology, vol. 34, no. 8, pp. 1101–1105, 2006.
- N. Nara, Y. Nakayama, S. Okamoto et al., “Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance,” Journal of Biological Chemistry, vol. 282, no. 42, pp. 30794–30803, 2007.
- T. D. Shellenberger, M. Wang, M. Gujrati et al., “BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells,” Cancer Research, vol. 64, no. 22, pp. 8262–8270, 2004.
- C. A. O'Brien, A. Pollett, S. Gallinger, and J. E. Dick, “A human colon cancer cell capable of initiating tumour growth in immunodeficient mice,” Nature, vol. 445, no. 7123, pp. 106–110, 2007.
- L. Ricci-Vitiani, D. G. Lombardi, E. Pilozzi et al., “Identification and expansion of human colon-cancer-initiating cells,” Nature, vol. 445, no. 7123, pp. 111–115, 2007.
- A. Castellanos, C. Vicente-Dueñas, E. Campos-Sánchez et al., “Cancer as a reprogramming-like disease: implications in tumor development and treatment,” Seminars in Cancer Biology, vol. 20, no. 2, pp. 93–97, 2010.
- S. R. Schwarze, J. Luo, W. B. Isaacs, and D. F. Jarrard, “Modulation of CXCL14 (BRAK) expression in prostate cancer,” Prostate, vol. 64, no. 1, pp. 67–74, 2005.
- M. Allinen, R. Beroukhim, L. Cai et al., “Molecular characterization of the tumor microenvironment in breast cancer,” Cancer Cell, vol. 6, no. 1, pp. 17–32, 2004.
- H. Pelicano, W. Lu, Y. Zhou et al., “Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism,” Cancer Research, vol. 69, no. 6, pp. 2375–2383, 2009.
- M. N. Wente, C. Mayer, M. M. Gaida et al., “CXCL14 expression and potential function in pancreatic cancer,” Cancer Letters, vol. 259, no. 2, pp. 209–217, 2008.
- S. Ozawa, S. Ito, Y. Kato, E. Kubota, and R. I. Hata, “Human p38δ MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14,” Biochemical and Biophysical Research Communications, vol. 396, no. 4, pp. 1060–1064, 2010.
- Y. Maehata, S. Ozawa, K. Kobayashi et al., “Reactive oxygen species (ROS) reduce the expression of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells,” Free Radical Research, vol. 44, no. 8, pp. 913–924, 2010.
- R. Komori, S. Ozawa, Y. Kato, H. Shinji, S. Kimoto, and R. I. Hata, “Functional characterization of proximal promoter of gene for human BRAK/CXCL14, a tumor-suppressing chemokine,” Biomedical Research, vol. 31, no. 2, pp. 123–131, 2010.
- R. Hata, “Regulation of CXCL14/BRAK, a tumor-suppressing chemokine, by MAP kinase subtype-specific crosstalk,” Seikagaku, vol. 83, no. 8, pp. 731–736, 2011.
- M. Pàez-Ribes, E. Allen, J. Hudock et al., “Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis,” Cancer Cell, vol. 15, no. 3, pp. 220–231, 2009.
- J. M. L. Ebos, C. R. Lee, W. Cruz-Munoz, G. A. Bjarnason, J. G. Christensen, and R. S. Kerbel, “Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis,” Cancer Cell, vol. 15, no. 3, pp. 232–239, 2009.
- K. Izukuri, S. Ito, N. Nozaki et al., “Determination of serum BRAK/CXCL14 levels in healthy volunteers,” Laboratory Medicine, vol. 41, no. 8, pp. 478–482, 2010.