A New Strategy to Find Targets for Anticancer Therapy: Chemokine CXCL14/BRAK Is a Multifunctional Tumor Suppressor for Head and Neck Squamous Cell Carcinoma

Table 1

CXC Chemokine ligands and their receptors.

Systematic name	CXC Chemokine		Chemokine receptor	Function
	Human	Mouse
ELR + chemokines
CXCL1	MGSA-𝛼/GRO-𝛼	GRO/MIP-2	CXCR2 > CXCR1	P
CXCL2	MGSA-𝛽/GRO-𝛽	GRO/MIP-2	CXCR2	P
CXCL3	MGSA-𝛾/GRO-𝛾	GRO/MIP-2	CXCR2	P
CXCL5	ENA-78	GCP2/LIX?	CXCR2	P
CXCL6	GCP-2	GCP2/LIX?	CXCR1, CXCR2	P
CXCL7	NAP-2	CRA-a,b	CXCR2	P
CXCL8	IL-8	Unknown	CXCR1, CXCR2	P
ELR − chemokines
CXCL4	PF-4	PF-4	CXCR3A and B	A/S
CXCL9	Mig	Mig	CXCR3	A
CXCL10	IP-10	IP10CRG2	CXCR3	A
CXCL11	I-TAC	I-TAC	CXCR3	A
CXCL12	SDF-1𝛼/𝛽	SDF1/PBSF	CXCR4, CXCR7	M, P
CXCL13	BCA-1	BLC	CXCR5	?
CXCL14	BRAK	BRAK (BMAC)	?	A/N/S
CXCL16	SR-PSOX	CXCL16	CXCR6	NT/S

A: angiostatic, M: metastatic, N: NK cell regulation, NT: NKT cell regulation, P: tumor progression, S: tumor suppression.