Research Article

Synthesis of New Fused Benzothiadiazepines and Macrocyclic Sulfamides Starting from N,N-Disubstituted Sulfamides and N(Boc)-Sulfamides

Scheme 2

General synthesis of tricyclic benzothiadiazepine-1,1-dioxides. Reagents and conditions: (f) α,α′-dibromo- 𝑜 - xylene, K2CO3, CH3CN, reflux, 4 h (g) K2CO3, 2,3,4,5-tetrakis(bromomethyl)benzene, CH3CN, reflux 10 h.
810938.sch.002