Research Article

Synthesis of New Fused Benzothiadiazepines and Macrocyclic Sulfamides Starting from N,N-Disubstituted Sulfamides and N(Boc)-Sulfamides

Table 1

IR, 1H NMR, and mass spectral data for compounds 4a-f and 4d′-f′.

Comp.   RRMN1H signals for aromatic region (δ : ppm)Yield [%]ESI (m/z)IR (KBr, ν cm−1)
SO2C=O

4aPropyl7.15 (s, 2H)765091148, 1339/
4bButyl7.16 (s, 2H)795671149, 1354/
4cBenzyl6.79 (s, 2H)757101157, 1357/
4dBenzyl7.13 (s, 2H)557211150, 13921715
4eCH2COOEt7.21 (s, 2H)487131139, 13801723, 1751
𝟒 𝐟 CH(CH3)COOMe7.13 (s, 2H)377131144, 13681732, 1745
𝟒 𝐝 Benzyl6.75 (s, 1H)7.27(s, 1H)157211155, 13711715
𝟒 𝐞 CH2COOEt7.05 (s, 1H)7.32 (s, 1H)247131139, 13801723, 1755
𝟒 𝐟 CH(CH3)COOMe7.00 (s, 1H)7.24(s, 1H)347131144, 13901732, 1750