In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets

Figure 1

In vitro comparative dissolution profile of reference drug Uroxatral (alfuzosin hydrochloride) extended release tablets 10 mg versus test drug alfuzosin hydrochloride extended release tablets 10 mg. Dissolution media is 0.1 (N) hydrochloric acid (a), acetate buffer (b), and phosphate buffer (c). Dissolution volume: 900 mL; apparatus USP-II (Paddle); RMP = 100; temperature (37°C ± 0.5°C).

(a)

(b)

(c)