Research Article
In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets
Table 2
Cumulative % drug release of the pilot batches in 0.1 N HCl.
| Time (h) |
Reference | Alfuzosin hydrochloride ER tablets 10 mg (% drug release) () | USP dissolution apparatus II (paddel) rpm 100; temperature 37°C ± 5°C | Batch | 25518 | F005 | F010 | F015 | F021 | F022 | F025 (optimal formulation) |
| 1 | 17.80 | 22.32 | 22.39 | 20.32 | 19.66 | 25.45 | 19.39 | 2 | 24.71 | 31.11 | 32.03 | 31.07 | 27.71 | 33.06 | 28.27 | 3 | 30.67 | 36.98 | 38.69 | 40.23 | 32.87 | 48.19 | 34.61 | 4 | 36.33 | 41.92 | 45.10 | 44.70 | 37.62 | 55.60 | 40.44 | 8 | 54.27 | 56.80 | 61.75 | 63.25 | 52.92 | 71.25 | 57.19 | 12 | 70.04 | 68.77 | 74.83 | 77.81 | 64.55 | 79.42 | 68.70 | 16 | 85.42 | 78.48 | 86.96 | 88.92 | 74.52 | 89.92 | 83.36 | 24 | 98.05 | 92.89 | 100.00 | 102.23 | 86.90 | 104.09 | 96.99 |
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