In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets

Table 2

Cumulative % drug release of the pilot batches in 0.1 N HCl.

Time (h)	Reference	Alfuzosin hydrochloride ER tablets 10 mg (% drug release) (𝑛=6)
		USP dissolution apparatus II (paddel) rpm 100; temperature 37°C ± 5°C
Batch	25518	F005	F010	F015	F021	F022	F025 (optimal formulation)
1	17.80	22.32	22.39	20.32	19.66	25.45	19.39
2	24.71	31.11	32.03	31.07	27.71	33.06	28.27
3	30.67	36.98	38.69	40.23	32.87	48.19	34.61
4	36.33	41.92	45.10	44.70	37.62	55.60	40.44
8	54.27	56.80	61.75	63.25	52.92	71.25	57.19
12	70.04	68.77	74.83	77.81	64.55	79.42	68.70
16	85.42	78.48	86.96	88.92	74.52	89.92	83.36
24	98.05	92.89	100.00	102.23	86.90	104.09	96.99