In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets

Table 4

Descriptive pharmacokinetics properties of the reference treatment under fasting conditions (𝑛=35).

Statistics	𝐾el	𝑇half	𝐶max	𝑇max	AUCT	AUCI	AUC_Exp
	(h^−1)	(h)	(ng/mL)	(h)	(ng/mL * h)	(ng/mL * h)
Mean	0.2679	7.89	10.2117	6.00	193.1723	196.4683	8.80
SD	0.10	0.47	2.23	0.69	12.0139	13.51	2.66
Min	0.1488	6.46	3.2445	0.33	119.1388	130.8190	4.92
Median	0.2191	7.16	8.3611	5.5	187.5498	180.5020	8.92
Max	0.4753	9.66	15.6322	8.00	250.6483	198.6327	15.53
CV%	37.13	30.13	26.89	50.55	36.22	37.04	30.26
Geometric mean	0.2524	7.75	10.9862	6.86	190.2896	193.2267	8.43
Harmonic mean	0.2397	7.59	10.6595	6.77	194.6518	199.2482	8.08