Developmental Neurotoxicity: Some Old and New Issues

Table 1

Examples of developmental neurotoxicants.

Category	Compound	Evidence of DNT
		Animals	Humans
	Methylmercury	+++++	+++++
Metals	Lead	+++++	+++++
	Manganese	+++	+++
	Arsenic	+++	++
Solvents	Ethanol	+++++	+++++
	Toluene	++++	+++++
	Organophosphates (various)	++	++
Pesticides	Organochlorines (dieldrin)	+	−−
	Herbicides (paraquat)	+	−−
	Fungicides (maneb)	+	−−
	PCBs	++++	+++
	PBDEs	+++	+
Other contaminants	Phtalates	++	++
	Bisphenol A	++	−−
	PFOS/PFOA	+	−−
Natural toxins	Domoic acid	++	−−
Pharmaceutical drugs	Antiepileptic compounds	++++	++++
Drugs of abuse	Cocaine	++	++

PCBs: polychlorinated biphenyls, PBDEs: polybrominated diphenyl ethers, PFOS/PFOA: perfluorooctane sulfate/perfluorooctanic acid. Symbols (+) are arbitrary evaluations by the authors.