Research Article
Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent
Table 1
Comparison of the performance characteristics of the proposed methods with the published methods.
| Sl. No. | Reagent/s used | Methodology | (nm) | Linear range | LOQ (μg mL−1) | Remarks | Ref. |
| (1) | ATP, NADH, NAD | Enzymatic | 340 | — | — | Requires vigorous control of experimental variables and expensive radiolabelled substrates, multiple reagents required. | [4] |
| (2) | -and π-donors | C-T complexation reaction | — | 5–225 μg mL−1 | 0.36–2.45 μg mL−1 | Less sensitive and multiple reagents used. | [5] |
| (3) | (a) p-dimethylamino- cinnamaldehyde and MBTH | Schiff base formation |
— | 10–50 μg mL−1 |
— | Poorly sensitive and expensive reagents used. |
[6] | (b) Iron(III)- MBTH | Oxidative coupling reaction | 50–250 μg mL−1 |
| (4) | Ce(IV)-rhodamine in H2SO4 medium | Chemiluminescence reaction | — | g mL−1 | g mL−1 | Requires complicated and expensive flow-injection assembly. | [7] |
| (5) | Ce(IV)-PDMAB IN 4 M HClO4 | Oxidative coupling reaction | 460 | 2–10 μg mL−1 | 0.15 μg mL−1 | Sensitive, inexpensive instrumental setup, use of ecofriendly chemicals, use of aqueous system. | This work |
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