Research Article

Titrimetric and Spectrophotometric Assay of Ganciclovir in Pharmaceuticals Using Cerium(IV) Sulphate as the Oxidimetric Agent

Table 1

Comparison of the performance characteristics of the proposed methods with the published methods.

Sl. No.Reagent/s usedMethodology 𝜆 m a x (nm)Linear rangeLOQ (μg mL−1)RemarksRef.

(1)ATP, NADH, NADEnzymatic340Requires vigorous control of experimental variables and expensive radiolabelled substrates, multiple reagents required.[4]

(2) 𝜎 -and π-donorsC-T complexation reaction5–225 μg mL−10.36–2.45 μg mL−1Less sensitive and multiple reagents used.[5]

(3)(a) p-dimethylamino-
cinnamaldehyde and MBTH
Schiff base formation10–50 μg mL−1Poorly sensitive and expensive reagents used. [6]
(b) Iron(III)- MBTHOxidative coupling reaction50–250 μg mL−1

(4)Ce(IV)-rhodamine in H2SO4 mediumChemiluminescence reaction 5 × 1 0 8  g mL−1 2 . 3 5 × 1 0 8  g mL−1Requires complicated and expensive flow-injection assembly.[7]

(5)Ce(IV)-PDMAB IN 4 M HClO4Oxidative coupling reaction4602–10 μg mL−10.15 μg mL−1Sensitive, inexpensive instrumental setup, use of ecofriendly chemicals, use of aqueous system.This
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