About this Journal Submit a Manuscript Table of Contents
ISRN Physical Chemistry
Volume 2012 (2012), Article ID 820653, 5 pages
http://dx.doi.org/10.5402/2012/820653
Research Article

Solubility Enhancement of Etoricoxib by Cosolvency Approach

Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Odisha, Mayurbhanj 757086, India

Received 27 January 2012; Accepted 1 March 2012

Academic Editors: A. Dkhissi, L. K. Shrestha, and N. A. Vodolazkaya

Copyright © 2012 Amit Kumar Nayak and Prachi Prava Panigrahi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of the present study was to examine and compare the cosolvency using three different cosolvents, namely PEG 400, PG, and glycerin on the aqueous solubility enhancement of a poorly aqueous soluble drug, etoricoxib, since solubilization of nonpolar drugs constitutes one of the important tasks in the formulation design of liquid dosage forms. The aqueous solubility of etoricoxib was 0 . 0 7 6 7 ± 0 . 0 0 1 8  mg/mL, which was significantly improved by the addition of PEG 400, PG, and glycerin as cosolvents. It was scrutinized that the less-polar solvents were found to increase the aqueous solubility by greater extent, thus accentuating hydrophobic interaction mechanism. Among various solvent-cosolvent blends investigated, water-PEG 400 showed highest solubilization potential. Thus, the study generated an important array of data to compare the effect of these cosolvents on the aqueous solubility of etoricoxib.